Maarten van der Doelen
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Chapter 1 General introduction and outline of the thesis Based on: Patient selection for radium-223 therapy in patients with bone metastatic castration resistant prostate cancer: new recommendations and future perspectives.
9
Chapter 2 Clinical outcomes and molecular profiling of advanced metastatic castration-resistant prostate cancer patients treated with 225Actiniumlabeled prostate-specific membrane antigen targeted alpha-radiation therapy.
27
Chapter 3 Immunophenotyping reveals longitudinal changes in circulating immune cells during radium-223 therapy in patients with metastatic castrationresistant prostate cancer.
53
Chapter 4 Health-related quality of life, psychological distress and fatigue in metastatic castration-resistant prostate cancer patients treated with radium-223 therapy.
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Chapter 5 Radium-223 therapy in patients with advanced castration-resistant prostate cancer with bone metastases. Lessons from daily practice.
133
Chapter 6 Early alkaline phosphatase dynamics as a biomarker of survival in metastatic castration-resistant prostate cancer patients treated with radium-223. European Journal of Nuclear Medicine and Molecular Imaging
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Chapter 7 Impact of DNA damage repair defects on response to radium-223 and overall survival in metastatic castration-resistant prostate cancer. European Journal of Cancer.
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Chapter 8 General discussion and future perspectivesBased on: Patient selection for radium-223 therapy in patients with bone metastatic castration resistant prostate cancer: new recommendations and future perspectives.
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Chapter 9 Summary
229
Samenvatting
235
List of abbreviations
243
List of contributing authors
245
List of publications and presentations
249
Research data management
253
PhD portfolio
255
Curriculum vitae
257
Dankwoord
261
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