Maarten van der Doelen

Patient-reported outcomes in mCRPC patients treated with radium-223 therapy

0.275

0.163

0.443

0.169

0.077

0.841

0.506

0.142

0.018

0.006

0.011

0.012

difference CRC P value

-

-

-

No

No

No

No

No

No

No

No

No

-0.3

-0.9

-0.5

-1.2

-0.9

+0.6

+1.1

+0.5

+0.2

+1.6

+2.3

+3.3

Mean

-

-

-

-

(4.0)

(4.0)

(3.5)

(3.5)

(6.9)

(6.9)

(13.2)

(13.2)

4

-

-

-

-

5.5

5.5

4.6

4.6

10.0

10.0

35.1

35.1

Time point T2

Mean (SD) score

(3.6) -

(3.7) -

(6.8) -

(13.0) -

(3.4)

(3.6)

(6.4)

(13.2)

-

-

-

31.9 -

4.5

4.4

4.2

4.1

8.7

8.5

31.7

Time point T1

Mean (SD) score

(3.8) -

(3.9) -

(7.4) -

(13.2) -

(3.8)

(4.1)

(7.5)

(13.6)

-

-

-

32.7 -

4.8

4.8

5.1

5.0

9.9

9.9

32.8

Time point T0

Mean (SD) score

time points N 58

58

56

56

56

56

58

56

56

58

56

56

Depression score T0-T1 T0-T2 T1-T2

Anxiety score T0-T1 T0-T2 T1-T2

Total score T0-T1 T0-T2

T1-T2

Fatigue severity subscale T0-T1 T0-T2 T1-T2

Comparison

Supplementary table 2B. Comparison of patient-reported outcomes on psychological distress and fatigue over time in patients receiving 6 radium-223 injections. HADS a CIS Fatigue a a High scores indicate high symptom burden. CRC, Clinically relevant change.

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