Maarten van der Doelen

Radium-223 therapy in advanced mCRPC patients

100

90

1-5 injections 6 injections

80

70

60

median OS 5.9 months

median OS 19.7 months

50

40

30

Overall survival (%)

20

10

0

0

3

6 9 12 15 18 21 24 27 30 33 36 39

Months since start of radium-223

Patients at risk 1-5 injections

24 21

22 21

12 21

7

5

2

2

2 7

2 6

2 4

1 1

0 1

0 1

0 0

6 injections

19 19

16

12

5

Figure 1. Kaplan-Meier cuve of overall survival (OS), stratified by number of injections received (1-5 versus 6 injections). Log-rank P-value < 0.001.

139