Maarten van der Doelen

Chapter 1

surrogate marker for overall survival. In chapter 7 , the potential of DNA damage repair mutation status as a biomarker of efficacy of radium-223 therapy and overall survival of mCRPC patients is described. Part III contains the general discussion in chapter 8 , in which the main findings are discussed and future perspectives are described. Finally, chapter 9 provides a summary of this thesis in both English and Dutch.

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