Maarten van der Doelen

Chapter 7

Supplementary table 1. Concomitant therapies. Study ID Concomitant therapy

DDR mutation

01

Enzalutamide

-

07

Abiraterone

-

08

Abiraterone

BRCA2 p.D252Qfs

14

Abiraterone

-

52

Sipuleucel-T

-

62

Sipuleucel-T

-

73

Abiraterone

PALB2 p.? (c.212-2A>G)

75

Enzalutamide

-

77

Sipuleucel-T

FANCG p.L53Afs

81

Enzalutamide

-

91

Enzalutamide

-

92

Enzalutamide

-

DDR, DNA damage repair.

Supplementary table 2. Administered number of radium-223 injections. Complete

Group DDR - N = 65

Group DDR + N = 28

cohort N = 93

P

Number of radium-223 injections, n (%) 1 injection

3 (3.2)

3 (4.6)

0 (0.0)

2 injections

5 (5.4)

5 (7.7)

0 (0.0)

3 injections

4 (4.3)

3 (4.6)

1 (3.6)

0.46

4 injections

8 (8.6)

6 (9.2)

2 (7.1)

5 injections

14 (15.1)

11 (16.9)

3 (10.7)

6 injections

59 (63.4)

37 (56.9)

22 (78.6)

DDR, DNA damage repair.

192