Maarten van der Doelen

Immunophenotyping during radium-223 therapy in mCRPC patients

Supplementary table 3. Bootstrap estimates and confidence interval of all cell subsets.

6-month change (% of baseline)

Cell subset

Lower bound of CI

Upper bound of CI

CD3

-22.1

-33.2

-10.5

CD14

27.2

13.2

42.8

CD4 +

Total

4

-3.9

12.9

CD45RO - CCR7 -

15.1

-4

42.9

CD45RO + CCR7 -

6.7

-6.2

23.7

3

CD45RO + CCR7 +

4.1

-4.3

14

CTLA-4

-6.7

-30

20.4

PD-L1

6.5

0.9

12.7

ICOS

43

14.6

75.1

PD-1

15.6

6

26.3

TIM-1

-16.4

-35.8

7.5

TIM-3

37.2

6.4

75.6

CD8 +

Total

-9.5

-21.9

2.7

CD45RO - CCR7 -

6.1

-5

18.3

CD45RO + CCR7 -

3.3

-6.2

13.9

CD45RO + CCR7 +

-6.5

-25.7

19.7

CTLA-4

-18.9

-38

6

PD-L1

8.3

2.2

14.9

ICOS

32.5

1.5

75.7

PD-1

11.4

-1

24.8

TIM-1

-2.7

-25.2

25.1

TIM-3

36.4

1.1

81.5

Tregs

25.1

14.3

38.2

Tregs CTLA

3.7

1.3

6.1

M-MDSC

113.3

33.6

239.6

M-MDSC PD-L1

14.4

0.1

37.1

9.9

-36.9

89.7

eMDSC

eMDSC PD-L1

-8.8

-21.3

6

CI, confidence interval.

75