Maarten van der Doelen

Chapter 4

Patients treated with radium-223 Informed consent obtained N = 124

Excluded from analysis n = 2

n = 2

Missing baseline questionnaire

Baseline HR-QoL questionnaire available Included for analysis n = 122

Lost to follow-up n = 8

n = 3 n = 5

Refused follow-up questionnaire Missing follow-up questionnaire

Discontinuation of therapy End-of-therapy HR-QoL questionnaire available n = 17

n = 2 n = 4

Discontinuation after first injection Discontinuation after second injection Discontinuation after third injection

n = 11

Continuing radium-223 therapy Follow-up HR-QoL questionnaire available after third radium-223 injection n = 97

Lost to follow-up n = 6

n = 1 n = 5

Refused follow-up questionnaire Missing follow-up questionnaire

Discontinuation of therapy End-of-therapy HR-QoL questionnaire available n = 16

n = 7 n = 9

Discontinuation after fourth injection Discontinuation after fifth injection

End-of-therapy HR-QoL questionnaire available after sixth radium-223 injection n = 75

Number of injections received n = 122

Number of injections received - grouped n = 122

n = 3 n = 8

One injection Two injections Three injections Four injections Five injections Six injections

n = 22 n = 23 n = 77

One – two – three injections

Four – five injections Six injections

n = 11 n = 13 n = 10 n = 77

Figure 1. Consort diagram of patient enrollment. HR-QoL, health-related quality of life.

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