Roel Bogie

Molecular pathways in post-colonoscopy versus detected colorectal cancers: Results from a nested case-control study

Table 10.3: Comparison of baseline characteristics between CRC cases with and without missing data. | CCA: complete case analysis.

Characteristic

CCA (n=162)

Imputed cases (n=58)

P value

PCCRC (%)

89 (54.9)

33 (56.9)

0.918

Mean age in years (SD)

71.0 (10.4)

70.0 (9.7)

0.499

Mean CRC size in cm (SD)*

4.07 (1.88)

4.05 (1.99)

0.959

Gender (% male)

93 (57.4)

34 (58.6)

0.996

Location CRC (% proximal)

85 (52.5)

23 (40.4)

0.156

Morphology (% flat)

66 (41.3)

19 (32.8)

0.328

TNM stage (% T1)

18 (11.1)

8 (14.5)

0.662

CRC differentiation (% good/intermediate) 119 (77.8)

39 (79.6)

0.945

Mucinosity (% >50% present)

19 (11.7)

11 (19.0)

0.248

*Size is missing in 4 cases.

Molecular feature analysis

All PCCRCs vs DCRCs Mutation

P value

OR [95% CI]

APC

0.97

1.01 [0.52 , 1.98] 1.04 [0.40 , 2.69] 0.94 [0.36 , 2.47] 0.89 [0.41 , 1.92] 0.99 [0.49 , 2.03] 0.96 [0.41 , 2.24] 1.34 [0.49 , 3.61] 0.80 [0.30 , 2.15] 0.75 [0.39 , 1.44] 0.39 [0.21 , 0.74] 1.59 [0.66 , 3.81] 1.38 [0.75 , 2.55]

BRAF

0.941 0.905 0.767 0.986 0.919 0.566 0.661 0.385 0.004 0.296 0.294

FBXW7

KIT

KRAS

10

PIC3CA

PTEN

SMAD4

TP53

18q loss

MSI

CIMP high

OR: PCCRCs vs detected CRCs 0 1 2 3 4

Figure 10.2a: Comparison of molecular features between post-colonoscopy colorectal cancers (PCCRCs) and detected colorectal cancers (DCRCs). | Forest plots showing the associations of several molecular features of PCCRCs compared to DCRCs.

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