Roel Bogie

ISBN: 978-94-6469-075-0

Copyright © Roel Bogie, Maastricht 2022 All rights reserved. No parts of this thesis may be reproduced or transmitted in any form or by any means, without prior permission in writing by the author, or when appropriate, by the publishers of the included individual publications.

Cover design and layout by Laura Jamar - Yume Design - www.yume-design.nl Printed by Ridderprint, www.ridderprint.nl

The work presented in this thesis was performed within the framework of GROW School for Oncology and Developmental Biology and CAPHRI School for Care and Public Health Reseach Institute (Maastricht University) .

Parts of this thesis were funded by an unrestricted educational grant by Pentax Medical b.v.

Printing of this thesis was financially supported by Maastricht University, and the Nederlandse Vereniging voor Gastroenterologie.