Roel Bogie

Endoscopic subtypes of colorectal laterally spreading tumors and risk of submucosal invasion: A meta-analysis

Prevalence of LSTs among all CRNs Author and Year x n

Prevalence [95% CI]

Xiang (2014)

172 4632

3.7 [3.2 , 4.3] 3.2 [2.5 , 4.0] 3.9 [3.4 , 4.4] 1.9 [1.5 , 2.4] 6.8 [6.2 , 7.5] 2.3 [1.3 , 3.8] 1.5 [1.1 , 2.0] 1.7 [1.0 , 2.9] 3.3 [2.7 , 3.9] 8.8 [6.4 , 11.6] 1.1 [0.6 , 1.7] 1.1 [0.6 , 2.0] 15.0 [11.3 , 19.3]

Dos Santos (2014) Rotondano (2011)

66

2067

254 6553

Kaku (2011)

62

3269

3

Matsuda (2010)

453 6638

Bustamente (2010) 14

613

Ciu (2009)

53 14

3494

Tantau (2008) Kil Lee (2008)

802

107 3263

Parra-Blanco (2006) 43

490

O'Brien (2004) Tsuda (2002)

16 11 49 18

1504

973 327 300

Rembacken (2000) Jaramillo (1995)

6.0 [3.6 , 9.3] 3.6 [2.5 , 4.9]

Total:

I 2 = 96.9%

0 5

15 10 Proportion (%)

20

Figure 3.4c: Forest plots showing prevalence estimates with 95% confidence intervals (Cis). | LSTs among all colorectal neoplasms (x, number of LSTs; n, number of colorectal neoplasms).

Prevalence of patients with ≥1 LST in the study population

0.005 0.004 0.002 0.001 0.000

Standard Error

0.00

0.00

0.01

0.01

0.02

0.02

0.03

Proportion (%)

Egger’s test z=4.53, P <0.001

Figure 3.5a: Funnel plot showing prevalence estimates of patients with one or more LSTs in the study population.

53