Roel Bogie

Chapter 3

LST-G-H LST-NG-FE Pooled prevalence of LST subtypes by location

27%

29%

73%

71%

Proximal Distal

Proximal Distal

Proximal: 73.3% (95% CI: 56.4 - 90.2) I : 95.2%; Q-test: P <0.001

Proximal: 71.3% (95% CI: 59.8 - 82.7) I : 80.4%; Q-test: P <0.001

LST-G-NM

LST-NG-PD

51% 49%

47% 53%

Proximal Distal

Proximal Distal

Proximal: 48.8% (95% CI: 27.1 - 70.5) I : 95.4%; Q-test: P <0.001

Proximal: 53.2% (95% CI: 29.9 - 76.5) I : 77.1%; Q-test: P =0.002

Figure 3.6b: Comparison of LSTs located in the proximal and distal colon. | Distribution of endoscopic LST subtypes throughout the colon. The Q test for heterogeneity was significant for all four analyses.

Location and endoscopic subtype There were 26 studies that examined the prevalence of LSTs by colonic location. Pooled prevalence of proximally located LSTs was 51.7% (95% CI: 47.1 – 56.3, I 2 : 89.7%, Figure 3.6a ). Granular LSTs were found significantly less often in the proximal colon than non-granular LSTs (OR 0.68, 95% CI: 0.48 – 0.97, I 2 : 77.1%, 17 studies). 9, 19, 26, 30, 32, 33, 36, 44, 45, 48, 51, 53, 54, 56, 58, 60, 62 The majority of homogenous granular and flat elevated non-granular LSTs were located in the proximal colon (73% and 71% respectively), while nodular mixed granular and pseudo-depressed non-granular LSTs were more evenly distributed over the colon (49% and 53% respectively in the proximal colon, Figure 3.6b , data from five studies). 19, 26, 30, 32, 54

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