Roel Bogie

Chapter 3

Prevalance of SMI in LSTs ≥ 20mm Author and year x n

Prevalence [95% CI]

Burgess (2017) Togashi (2014) Terasaki (2012) Huang (2009) Tantau (2008) Kudo (2008) Uraoka (2006) Oka (2009)

124 1831

6.8 [5.7 , 8.0]

9 9

47

19.1 [9.1 , 33.3] 3.4 [1.6 , 6.3] 9.0 [7.1 , 11.2] 11.2 [5.3 , 20.3] 25.0 [5.3 , 57.2] 15.1 [11.4 , 19.5] 16.2 [11.8 , 21.5] 19.2 [6.6 , 39.4] 15.0 [9.1 , 22.7] 11.3 [8.2 , 14.4]

267 768

69

9 3

80 12

49 39

324 240

Kim (2003)

5

26

Tanaka (2001)

28

120

Total:

I 2 = 85.1%

0

45 30 Prevalence (%) 15

60

Figure 3.12: Forest plot showing prevalence estimates of submucosal invasion in LSTs ≥20mm.

SMI in distal vs proximal LSTs % SMI Author and year Dist. Prox.

OR [95% CI]

Zhao (2014) Kim (2011) Kaji (2011)

12.6 5.7

2.39 [0.86 , 6.64] 2.33 [0.65 , 8.32] 2.97 [0.70 , 12.64] 2.50 [1.24 , 5.02]

10 14

4.5 5.2

Total: I 2 = 0%

16 4 OR SMI distal/proximal 1 0.25

Figure 3.13: Forest plot of the pooled odds ratio (OR) of submucosal invasion (SMI) in distally vs proximally located LSTs.

Table 3.4: Risk of submucosal invasion in laterally spreading tumors, stratified by size.

Size

10-19 mm

20-29 mm

≥ 30 mm

Risk to contain submucosal invasion Heterogeneity index ( I2 )

4.6% (95% Cl: 3.1 - 6.0%)

9.2% (95% Cl: 6.6 - 11.8%)

16.5% (95% Cl: 9.8 - 23.3%)

31.6%

14.1%

69.5%

1, 37, 38, 57, 58, 62, 66, 68

1, 37, 57, 58, 68

1, 37, 57, 58, 68

References

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