Maarten van der Doelen

Chapter 4

0.548

0.165

0.584

0.167

0.495

0.801

0.770

0.321

0.104

0.150

0.962

0.012

0.032

0.014

0.002

0.004

0.009

0.042

0.024

<0.001

<0.001

difference CRC P value

None

None

None

None

None

None

None

None

None

None

None

None

None

Small

Small

Small

Small

Small

Small

Moderate

Moderate

-1.2

-4.3

-1.3

-3.6

-6.9

-7.7

-2.4

-3.8

-2.3

-6.8

-5.0

-0.2

-7.1

-7.3

+3.0

+1.3

+2.2

+0.5

+0.7

+11.7

+10.8

Mean

-

-

-

-

-

-

-

(18.6)

(18.6)

(27.1)

(27.1)

(15.3)

(15.3)

(22.5)

(22.5)

(24.8)

(24.8)

(25.4)

(25.4)

(30.2)

(30.2)

-

-

-

-

-

-

-

78.1

78.1

46.4

46.4

84.9

84.9

58.8

58.8

78.4

78.4

66.9

66.9

59.1

59.1

Time point T2

Mean (SD) score

(16.4) -

(22.3) -

(15.2) -

(18.2) -

(24.7) -

(22.6) -

(30.1) -

(16.5)

(22.3)

(15.2)

(18.2)

(24.6)

(22.0)

(30.1)

82.6 -

35.8 -

88.6 -

66.2 -

81.8 -

71.2 -

66.0 -

82.4

35.6

88.4

66.4

82.2

71.9

66.4

Time point T1

Mean (SD) score

(21.9) -

(17.2) -

(16.7) -

(21.9) -

(22.1) -

(29.4) -

(20.3) -

(21.8)

(17.2)

(16.6)

(21.8)

(22.1)

(29.2)

(20.3)

65.7 -

34.7 -

86.2 -

80.9 -

73.8 -

66.2 -

79.3 -

Mean (SD) score 65.7

34.5

86.4

81.1

73.5

66.2

79.6

Time point T0

time points N 76

75

75

76

75

75

76

75

75

76

75

75

76

75

75

76

75

75

76

75

75

QLQ-C30 functional scales a Global health status T0-T1 T0-T2 T1-T2

QLQ-C30 symptom scales b Fatigue T0-T1 T0-T2 T1-T2

Cognitive functioning T0-T1 T0-T2 T1-T2

Social functioning T0-T1 T0-T2 T1-T2

Physical functioning T0-T1 T0-T2 T1-T2

Role functioning T0-T1 T0-T2 T1-T2

Emotional functioning T0-T1 T0-T2 T1-T2

Comparison

Supplementary table 2A. Comparison of patient-reported outcomes on cancer-specific and bone metastases-related health-related quality of life over time in patients receiving 6 radium-223 injections.

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