Maarten van der Doelen

Patient-reported outcomes in mCRPC patients treated with radium-223 therapy

0.261

0.103

0.479

0.880

1.000

0.885

1.000

0.402

0.203

0.181

0.698

1.000

0.718

0.557

0.948

0.286

0.015

0.002

difference CRC P value +5.3 Small 0.002

0.044

0.040

0.011

<0.001

<0.001

None

None

None

None

None

None

None

None

None

None

None

Moderate None

None

None

None

None

None

Small

Small

Moderate Small

Small

0.0

0.0

0.0

-0.4

-0.9

-2.0

+0.4

+3.5

+5.3

+2.2

+0.9

+7.0

+9.3

+2.2

+2.7

+4.9

+0.2

+2.4

+4.8

+8.4

+4.0

+16.0

+10.0

Mean

-

-

-

-

-

-

-

-

(27.9)

(27.9)

(22.8)

(22.8)

(18.7)

(18.6)

(33.9)

(33.9)

(23.3)

(23.3)

(20.9)

(20.9)

(27.5)

(27.5)

(27.4)

(27.4)

4

-

-

-

-

-

-

-

-

7.7

7.6

20.4

20.4

15.1

15.1

27.6

27.6

13.8

13.8

Time point T2 15.1

Mean (SD) score 15.1

34.0

34.0

23.1

23.1

(26.6) -

(22.6) -

(25.2) -

(27.4) -

(21.6) -

(16.9) -

(27.8) -

(29.9) -

(26.7)

(21.8)

(25.2)

(25.9)

(20.7)

(15.7)

(27.3)

(29.6)

-

13.6 -

19.3 -

11.8 -

11.0 -

20.6 -

32.2 -

19.7 -

8.4

8.4

12.9

18.2

11.1

Mean (SD) score 10.2

20.9

31.6

19.1

Time point T1

(26.2) -

(18.7) -

(22.9) -

(21.6) -

(13.1) -

(25.6) -

(27.4) -

(25.3) -

(26.1)

(18.6)

(23.6)

(21.6)

(14.0)

(25.6)

(27.5)

(25.2)

-

-

11.6 -

11.6 -

-

20.4 -

33.8 -

14.7 -

9.8

7.6

7.7

Time point T0 5.7 5.1

12.3

11.8

10.1

20.2

34.2

14.9

Mean (SD) score

time points N 76 75

75

74

75

76

75

75

76

75

75

76

75

75

75

76

75

75

76

75

75

76

75

75

Financial difficulties T0-T1 T0-T2 T1-T2

Appetite loss T0-T1 T0-T2 T1-T2

Constipation T0-T1 T0-T2 T1-T2

Diarrhoea T0-T1 T0-T2

T1-T2

Nausea/vomiting T0-T1 T0-T2 T1-T2 Pain T0-T1

Insomnia T0-T1 T0-T2

T1-T2

T0-T2

T1-T2

Dyspnoea T0-T1 T0-T2

T1-T2

Comparison

Supplementary table 2A. Continued.

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