Maarten van der Doelen

Patient-reported outcomes in mCRPC patients treated with radium-223 therapy

BM-22 functional scales a Functional interference T0-T1 17 74.3 (24.0) 59.8 (24.7) -14.5 Moderate 0.020 Psychosocial aspects T0-T1 17 58.2 (23.4) 50.0 (24.6) -8.2 Small 0.038

Fatigue severity subscale T0-T1 15 30.3 (16.5) 39.6 (16.0) +9.3 - 0.005

Anxiety score T0-T1 15 5.1 (4.0) 7.6 (5.5) +2.5 Yes 0.014

Depression score T0-T1 15 6.8 (6.0) 10.1 (5.9) +3.3 Yes 0.011

Total score T0-T1 15 11.9 (9.6) 17.7 (10.5) +5.8 Yes 0.007 CIS Fatigue a

difference CRC P value

difference CRC P value

Mean

Mean

4

Time point T1

Time point T1

Mean (SD) score

Mean (SD) score

Time point T0

Time point T0

Mean (SD) score

Mean (SD) score

time points N

time points N

Comparison

Comparison

Supplementary table 3A. Continued.

Supplementary table 3B. Comparison of patient-reported outcomes on psychological distress and fatigue over time in patients receiving 1-3 radium-223 injections. HADS a

Mean health-related quality of life scores range from 0 to 100. a Functional and global scales: high scores indicate high level of functioning. b Symptom scales: high scores indicate high symptom burden. CRC, Clinically relevant change, defined as small (5-10 points), moderate (10-20 points), or large (>20 points). a High scores indicate high symptom burden.

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