Maarten van der Doelen

Chapter 4

0.496

0.666

0.072

0.083

0.390

0.225

0.126

0.527

0.022

0.024

0.041

0.001

0.003

0.019

0.034

0.025

0.001

0.001

<0.001

<0.001

<0.001

None

None

None

Small

Small

Small

Small

Small

Large

Large

Moderate Large

Large

Large

Large

Large

Moderate

Moderate

Moderate

Moderate

Moderate

-3.2

-8.3

-9.4

-7.1

-7.9

-5.5

+1.6

+5.4

-13.0

-11.5

-22.9

-15.6

-24.5

-20.8

-18.3

-13.3

-31.3

-28.1

+12.7

+34.7

+20.8

Mean difference CRC P value

-

-

-

-

-

-

-

(24.8)

(24.8)

(27.2)

(27.2)

(27.5)

(27.5)

(21.9)

(21.9)

(18.2)

(18.2)

(22.4)

(22.4)

(21.8)

(21.8)

-

-

-

-

-

-

-

56.8

56.8

66.7

66.7

51.0

51.0

36.5

36.5

68.8

68.8

53.8

53.8

31.3

31.3

Time point T2

Mean (SD) score

(26.1) -

(20.1) -

(29.0) -

(26.7) -

(21.3) -

(26.7) -

(32.1) -

(25.9)

(20.2)

(32.2)

(20.2)

(21.0)

(22.9)

(28.5)

69.4 -

77.0 -

69.0 -

64.1 -

47.1 -

64.1 -

54.8 -

68.2

76.0

66.7

57.3

47.9

67.1

59.4

Time point T1

Mean (SD) score

(22.8) -

(29.2) -

(18.7) -

(23.1) -

(22.2) -

(30.7) -

(26.7) -

(23.3)

(27.7)

(22.0)

(24.6)

(22.4)

(35.1)

(26.8)

75.0 -

74.0 -

60.9 -

34.0 -

72.1 -

62.5 -

69.8 -

75.4

76.2

58.7

34.4

72.1

60.3

72.6

Time point T0

Mean (SD) score

time points N

21

16

16

21

16

16

21

16

16

21

16

16

21

16

16

21

16

16

21

16

16

Cognitive functioning T0-T1 T0-T2 T1-T2

Social functioning T0-T1 T0-T2 T1-T2

QLQ-C30 functional scales a Global health status T0-T1 T0-T2 T1-T2

QLQ-C30 symptom scales b Fatigue T0-T1 T0-T2 T1-T2

Physical functioning T0-T1 T0-T2 T1-T2

Role functioning T0-T1 T0-T2 T1-T2

Emotional functioning T0-T1 T0-T2 T1-T2

Comparison

Supplementary table 4A. Comparison of patient-reported outcomes on cancer-specific and bone metastases-related health-related quality of life over time in patients receiving 4-5 radium-223 injections.

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