Maarten van der Doelen

Patient-reported outcomes in mCRPC patients treated with radium-223 therapy

0.736

0.384

0.743

0.129

0.214

0.071

0.229

0.174

0.009

0.044

0.016

<0.001

-

-

-

No

No

No

No

No

No

Yes

Yes

Yes

+0.3

+0.9

+0.3

+1.3

+3.5

+2.2

+3.6

+8.2

+2.9

+1.6

+4.5

+2.5

Mean difference CRC P value

-

-

-

-

(4.8)

(4.8)

(5.0)

(5.0)

(8.7)

(8.7)

(8.8)

(8.8)

-

-

-

-

4

7.7

7.7

10.1

10.1

44.8

44.8

17.8

17.8

Time point T2

Mean (SD) score

(3.8) -

(3.9) -

(11.5) -

(6.3) -

(3.5)

(3.8)

(8.6)

(5.9)

-

-

40.1 -

14.6 -

6.9

7.4

7.8

7.9

41.9

15.3

Time point T1

Mean (SD) score

(8.9) -

(3.0) -

(3.9) -

(6.0) -

(3.1)

(3.8)

(6.2)

(11.9)

-

-

36.6 -

13.3 -

6.6

6.8

6.4

6.5

36.6

13.1

Time point T0

Mean (SD) score

time points N 16

13

13

16

13

13

16

13

13

16

13

13

Anxiety score T0-T1 T0-T2 T1-T2

Depression score T0-T1 T0-T2 T1-T2

Fatigue severity subscale T0-T1 T0-T2 T1-T2

Total score T0-T1 T0-T2

T1-T2

Comparison

Supplementary table 4B. Comparison of patient-reported outcomes on psychological distress and fatigue over time in patients receiving 4-5 radium-223 injections HADS a CIS Fatigue a a High scores indicate high symptom burden. CRC, Clinically relevant change.

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