Roel Bogie

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Chapter 10

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Alternations Mutation

0 10 20 30

APC

TP53

KRAS

KIT

BRAF

PIK3CA

PTEN

FBXW7

SMAD4 SRC

AKT1

ATM

RB1

STK11

VHL

EGFR

FGFR1

FGFR3

GNA11

GNAQ

HNF1A

KDR

NOTCH1 NRAS

CTNNB1

ERBB2

ERBB4

FLT3

HRAS

MET

RET

ABL1

CDH1

CSF1R

FGFR2

IDH1

MPL

PDGFRA

SMARCB1 SMO ALK

CDKN2A GNAS

JAK2

JAK3

MLH1

NPM1

PTPN11

1368 1091 1382 1372 1237 1358 1369 1386 1064 1302 1371 1291 1242 1219 1128 1212 1232 1234 1099 1379 1016 1035 1250 1364 1295 1205 1311 1257 1178 1214 1380 1304 1373 1080 1011 1022 1152 1134 1126 1292 1376 1045 1377 1186 1238 1202 1037 1370 1014 1053 1277 1366 1235 1150 1125 1140 1343 1033 1262 1384 1231 1052 1043 1054 1190 1286 1383 1039 1332 1030 1058 1131 1026 1103 1215 1221 1175 1275 1213 1280 1243 1040 1116 1027 1047 1073 1143 1183 1191 1217 1313 1362 1367

Figure 10.5: Mutation frequencies detected in PCCRCs and DCRCs. | Oncoprint matrix showing the 48 tested genes (rows) in CRC cases (columns). Blue coloured block: mutations detected; grey coloured block: no mutation detected. Left panel: results of PCCRCs; right panel: results DCRCs.

OncoPrint 48 genes capture panel; PCCRCs

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