Roel Bogie

Molecular pathways in post-colonoscopy versus detected colorectal cancers: Results from a nested case-control study

Alternations Mutation

0 10 20 30 40

APC

TP53

KRAS

KIT

PIK3CA

FBXW7

SMAD4 VHL

BRAF

GNA11 RB1

NRAS

HNF1A

HRAS

PTEN

SMO

SRC

ATM

CDH1

ABL1

AKT1

GNAQ

STK11

ERBB4

FGFR3

KDR

PDGFRA

CDKN2A EGFR

ERBB2

FGFR2

MET

MLH1

NPM1

SMARCB1 ALK

CSF1R

CTNNB1

FGFR1

FLT3

GNAS

IDH1

JAK2

JAK3

MPL

NOTCH1

PTPN11 RET

1137 1323 1012 1199 1129 1336 1142 1105 1210 1318 1086 1180 1216 1319 1324 1117 1050 1066 1070 1092 1093 1274 1029 1046 1136 1296 1168 1167 1300 1268 1154 1355 1252 1320 1159 1107 1146 1298 1335 1265 1170 1227 1297 1121 1264 1072 1290 1095 1330 1163 1010 1048 1113 1144 1278 1071 1174 1256 1253 1075 1181 1347 1096 1312 1357 1160 1342 1266 1051 1036 1005 1114 1309 1007 1139 1164 1211 1348 1351

10

OncoPrint 48 genes capture panel; Detected CRCs

Figure 10.5: ( continuation)

5

0

10

9%

9%

8%

8%

8%

8%

6%

6%

5%

5%

4%

4%

4%

4%

3%

3%

3%

3%

1%

1%

1%

1%

1%

1%

1%

1%

0%

0%

0%

0%

0%

0%

0%

0%

0%

0%

0%

0%

0%

49%

48%

30%

23%

16%

11%

11%

11%

10%

201

Alternations Mutation

0 10 20 30

A

7

4

CB1

2A

H1

RA

B1

1

2

4

1

3

2

11

A

R