Maarten van der Doelen

Patient-reported outcomes in mCRPC patients treated with radium-223 therapy

1.000

0.789

0.289

0.206

0.493

0.580

0.718

0.110

0.793

0.361

0.572

0.602

0.021

0.001

0.007

0.035

0.048

0.002

0.001

0.004

0.023

0.047

0.002

0.029

Moderate None

None

None

None

None

None

Moderate None

None

Small

Large

Large

Moderate Large

Large

Large

Moderate Large

Moderate

Moderate

Moderate

Moderate

Moderate

0.0

-3.2

-2.1

-4.8

+2.1

+1.6

+7.9

+1.6

+4.2

+14.3

+14.6

+10.4

+10.4

+11.1

+33.3

+22.9

+31.3

+20.8

Mean difference CRC P value +10.4 +20.8 +19.8 +15.9 +29.2 +14.6

-

-

-

-

-

-

-

-

(27.2)

(27.2)

(35.4)

(35.4)

(29.5)

(29.5)

(34.4)

(34.4)

(31.5)

(31.5)

(14.9)

(14.9)

(29.8)

(29.8)

(28.5)

(28.5)

-

-

-

-

-

-

-

-

4

8.3

8.3

16.7

16.7

31.3

31.3

54.2

54.2

33.3

33.3

Time point T2 21.9

Mean (SD) score 21.9

57.3

57.3

41.7

41.7

(32.4) -

(22.3) -

(26.8) -

(19.7) -

(20.1) -

(15.9) -

(30.5) -

(29.6) -

(27.2)

(20.6)

(28.5)

(20.6)

(21.5)

(18.1)

(28.9)

(25.0)

20.6 -

-

31.7 -

12.7 -

15.9 -

34.1 -

30.2 -

20.6 -

4.8

6.3

16.7

31.3

12.5

Mean (SD) score 17.7

37.5

27.1

20.8

Time point T1

(8.3) -

(36.3) -

(8.3) -

(20.1) -

(23.3) -

(28.0) -

(20.6) -

(24.0) -

(22.7)

(34.1)

(18.0)

(26.5)

(12.0)

(30.0)

(22.5)

(22.5)

-

20.8 -

10.4 -

11.5 -

-

36.5 -

12.5 -

20.8 -

6.3

2.1

7.9

4.8

2.1

20.6

Time point T0 14.3

38.9

14.3

19.0

Mean (SD) score

time points N 21 16

21

16

16

21

16

16

21

16

16

16

21

16

16

21

16

16

21

16

16

21

16

16

Diarrhoea T0-T1 T0-T2

T1-T2

Financial difficulties T0-T1 T0-T2 T1-T2

Appetite loss T0-T1 T0-T2 T1-T2

Nausea/vomiting T0-T1 T0-T2 T1-T2 Pain T0-T1

Constipation T0-T1 T0-T2 T1-T2

T0-T2

T1-T2

Dyspnoea T0-T1 T0-T2

T1-T2

Insomnia T0-T1 T0-T2

T1-T2

Comparison

Supplementary table 4A. Continued.

125